Director/Senior Director - Neurology

09 Aug 2017
06 Sep 2017
Contract Type
Full Time

Title: Director - Neuroscience Physician

Location: Cambridge, UK

Salary: Competitive

At MedImmune, relentless pursuit is matched with exceptional capabilities to break new ground in science. We have one of the most robust pipelines in the industry, and it's because of our people. We're entrepreneurial and deeply collaborative - a winning combination that's delivering life-changing medicines to patients. We offer a unique and strong collaborative network as part of the AstraZeneca family, as together we explore synergies between small and large molecules.

AstraZeneca's Neuroscience team is a unique construct that comprises a small team of expert scientists delivering a world-class portfolio of life-changing medicines to patients. We operate autonomously and creatively, with freedom to pursue creative and innovative solutions to diseases of the nervous system, and have a broad network of external collaborators to help us deliver exceptional science.

The Neuroscience Unit in Cambridge is now seeking to recruit a Physician at Director level with a Neuroscience background. This is an exciting opportunity to join a unique 'biotech' team within industry. The role will report to the Senior Medical Director in Neurosciences, and carries accountabilities for delivery of the Neuroscience portfolio of small and large molecules through late discovery and early clinical development using internal and external resources. The successful candidate will support or lead projects transitioning from discovery through the early stages of clinical development (Phase I to completion of Phase II). They will be accountable as project physician for the conduct of clinical studies in line with defined operating procedures, including study design, development of the clinical protocol and operational aspects.

As a member of the AstraZeneca IMED, the Project physician will be directly accountable for the conduct of one or more projects in the Neuroscience portfolio assigned to them. Role responsibilities include (but are not limited to):

  • Creation of the scientific strategy, development plan and approach to the project in order to ensure optimal execution and delivery from candidate to end of Phase II.
  • Representation of the project at key milestones to relevant governance committees e.g. Candidate Drug Nomination, First Time in Human study review, Phase II investment decision.
  • Playing an active role in planning, conducting and evaluating clinical trials and supervising cross functional team members to ensure successful trial delivery
  • Serving as sponsor medical monitor and associated activities for clinical trials with significant responsibility for safety surveillance.
  • Reviewing and interpreting study results as appropriate and presenting these internally and externally (e.g. via publication) as needed.
  • Selection and management of collaborators and vendors including academic groups, CROs, and technical expertise or services within AZ/Medimmune.
  • Contributing to development of disease area strategies that integrate discovery research with clinical approaches to proof-of-concept in appropriate patient segments.
  • Evaluating and recommending licensing and acquisition opportunities, in balance with internal IMED efforts, and in partnership with other IMED LT members, and where required, actively participating in co-partnering discussions with external business partners.

Essential requirements

  • Significant experience in clinical research is required, allowing the candidate to demonstrate the successful design and conduct of GCP compliant trials, most likely within a pharmaceutical or biotechnology company environment.
  • Significant experience of clinical development for product(s) targeted to neuroscience indications would be an advantage. Experience of the principles of Translational Science in the context of early clinical development, ultimately aiming to target medicines to specific patient populations with the optimal benefit: risk is desirable.
  • You must be an excellent communicator and collaborative worker with proven leadership skills and the ability to interact in a cross functional environment with both internal and external business partners.
  • You must be capable of integrating and analysing non-clinical and clinical data as well as data/input from multiple internal and external functional areas. Synthesis of previous clinical data and ongoing medical safety data is required on daily basis. You must manage multiple tasks/programs with competing deadlines/priorities.
  • You must be able to operate independently in medical, safety and clinical development tasks with minimal supervision. Once direction is provided, you must identify problems, generate solutions (or options) and either execute recovery plan (or seek advice depending on strategic impact to company)
  • We are seeking a physician with experience in clinical neurology or specialist training in neurology; alternatively, a physician with a significant background in neurological/neurodegeneration clinical research.
  • You are also educated to MD, MBBS, MBChB or equivalent level.

Opening date: June 7th 2017

Closing date: August 31st 2017

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.